Are All PGx Tests Created Equal?

Evaluating the Best Provider for Your Needs

As pharmacogenomics (PGx) gains traction in personalised medicine, more healthcare providers are considering offering these tests to their patients. But with the growing number of PGx test providers, a critical question arises: Are all PGx tests created equal? Here’s what healthcare professionals should consider when selecting a PGx test provider. 

Understanding the Differences Among PGx Tests

Not all PGx tests are the same. The differences can stem from the number and types of genes analysed, the quality of the test, the interpretation of results, and the overall service provided by the testing company.  

 1. Gene Coverage: How Comprehensive is the Test?

Some PGx tests cover a wide range of genes related to drug metabolism, efficacy, and safety, while others may focus on a narrower set of genes. When choosing a PGx test, it’s important to consider whether the genes included are relevant to the medications commonly prescribed to your patients. 

Best Practice: Select a test that includes key pharmacogenes such as CYP2D6, CYP2C19, and SLCO1B1, which are well-documented in influencing drug response.

2. Analytical Validity: Is the Test Accurate and Reliable?

The accuracy of a PGx test depends on the quality of the laboratory processes, including how the test is conducted and how results are interpreted. Look for tests that are performed in accredited laboratories with high standards for quality control.

Best Practice: Choose a provider whose tests are performed in laboratories accredited by recognized bodies such as the UK Accreditation Service (UKAS) or equivalent international organisations.

3. Clinical Utility: How Useful Are the Results in Practice?

The clinical utility of a PGx test is determined by how well the test results can guide medication decisions. Tests should provide actionable insights that can directly influence prescribing practices, reducing the risk of adverse effects and improving treatment efficacy.

Best Practice: Opt for tests that offer clear, evidence-based recommendations for clinicians, ideally integrated with current clinical guidelines.

4. Result Interpretation: How Easy is It to Understand the Results?

PGx tests generate complex data that must be interpreted correctly to be useful. Providers that offer robust support for result interpretation—such as detailed reports, access to clinical pharmacogenomic experts, and integration with electronic health records - can significantly enhance the utility of the test. 

Best Practice: Ensure the provider offers comprehensive support for interpreting results, including easy-to-understand reports and, if needed, direct consultation with experts.

5. Patient Support: Is There Assistance for Patients Post-Test?

Beyond the technical aspects, consider the level of support the provider offers to patients or the healthcare practitioner. Good providers will offer post-test counselling and support to help patients understand their results and any implications for their medication regimen. Best Practice: Choose providers that offer strong patient education and counselling services, ensuring patients fully understand their test results and any necessary next steps.

Making the Best Choice for Your Patients

When choosing a PGx test provider, it’s essential to consider the specific needs of your practice and your patients. Not all tests are created equal, and selecting the right provider involves assessing the comprehensiveness of the test, the reliability of the laboratory, the clinical utility of the results, and the level of support offered.

In the rapidly evolving field of pharmacogenomics, staying informed about the quality and capabilities of different PGx test providers will ensure that you can offer the best possible care to your patients. By carefully evaluating these factors, you can make a well-informed decision that enhances patient outcomes and supports the broader adoption of personalised medicine in your practice. 

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