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- Genotyping
State-of-the-art genotyping services - Pharmacogenetics
Personalised approach to prescribing medications - Metagenomic Sequencing
Profiling of gut, oral and vaginal microbiome - Bloodborne Infection Screening
Detection of key blood-borne infections. - Contract Research
Tailored solutions support for the entire assay lifecycle
PGx FOR GENITOURINARY MEDICINE
Optimise Hormone Function
AttoDiagnostics’ Pharmacogenomics Testing supports genitourinary medicine practitioners in tailoring therapies, reducing the risk of adverse drug reactions, and optimising patient outcomes.
- Covers key medications, including hormonal contraceptives and hormone therapies
- Identifies genetic factors, such as F2 and F5 variations, that influence drug response
- Reduces risk of adverse events, including venous thromboembolism
- UK-based laboratory
Pharmacogenomics for Genitourinary Medicine
Prescribing medications for genitourinary conditions is becoming increasingly complex due to genetic influences on treatment efficacy and the risk of venous thromboembolism in individuals with F2 and F5 gene mutations. As a result, many medications now incorporate genetic guidance into prescribing recommendations—an essential consideration for doctors, urologists, and sexual health practitioners.
AttoDiagnostics' state-of-the-art PGx testing solution utilises Thermofisher and Illumina platforms alongside a world-class Clinical Decision Support System (CDSS), drawing on the latest research and guidelines from CPIC, PharmGKB, FDA, DPWG, and other leading organisations. By providing actionable insights based on each patient’s genetic profile, our service supports the safe and effective prescribing of sex hormone therapies and contraceptive treatments. Explore the key benefits below.
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Personalised Medication Management
PGx testing identifies the most appropriate medications for each patient by analysing their genetic profile. This approach reduces reliance on trial and error, enabling faster therapeutic success while lowering the risk of adverse drug reactions, including nephrotoxicity, hormonal imbalances, antimicrobial resistance, nausea, and dizziness.
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Enhanced Efficacy and Reduced ADRs
By selecting medications most likely to be effective based on genetic markers, PGx testing improves treatment outcomes and enhances clinical safety. It helps identify patients at higher risk of adverse reactions, supporting more informed prescribing decisions and better overall patient care.
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Optimised Dosage
Genetic insights inform dosage adjustments tailored to each patient’s metabolic profile, allowing for more precise administration of higher or lower doses as needed. Personalised dosing enhances treatment efficacy and minimises the risk of side effects.
What Our Pharmacogenomics Report Covers
Our PGx report includes two main sections. A quick overview providing a concise review of medication suitability, including recommendations for standard dosing, dose modifications, or avoidance where necessary. This is followed by a detailed gene-by-gene analysis exploring genetic variants and their potential interactions with prescribed medications, offering deeper clinical insights to guide treatment decisions.
Pharmacogenomics Testing Panel for Genitourinary Medications
AttoDiagnostics offers targeted PGx panels to optimise the use of medications commonly prescribed in genitourinary medicine, including contraceptives, topical and systemic estrogens, combination therapies, progestogens, and antiandrogens.
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How Pharmacogenomic Testing Works
Pharmacogenomic testing is a simple, non-invasive procedure involving the collection of a buccal swab, performed at home. The swab captures DNA from the inner cheek, allowing us to analyse genetic variations relevant to drug metabolism and response, particularly for medications commonly prescribed in genitourinary medicine such as hormonal contraceptives and hormone replacement therapies.
Step 1
Sample Collection
Our preferred method is the collection of a buccal swab sample. Swabs are easy to use, stable for transportation by post, and suitable for flexible collection either onsite or remotely.
Step 2
Genetic Analysis
Samples are analysed at our accredited UK-based laboratory using Thermo Fisher or Illumina platforms, with a validated panel of drug-metabolising enzymes (DMEs) and transport proteins relevant to genitourinary treatments.
Step 3
Comprehensive Report
The PGx report details the clinical implications of the patient’s genetic profile, providing a quick reference overview and, where needed, a more detailed analysis of medication selection, dosing guidance, and potential drug-drug interactions, ensuring personalised, safe, and effective patient care.
